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The Ultrasound Journal
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  • Review Article
  • Open Access

Echocardiography in the sepsis syndromes

Critical Ultrasound Journal20113:69

https://doi.org/10.1007/s13089-011-0069-0

©  Springer-Verlag 2011

  • Received: 3 February 2011
  • Accepted: 15 April 2011
  • Published:

Abstract

Purpose of the review

Non-invasiveness and instantaneous diagnostic capability are prominent features of the use of echocardiography in critical care. Sepsis and septic shock represent complex situations where early hemodynamic assessment and support are among the keys to therapeutic success. In this review, we discuss the range of applications of echocardiography in the management of the septic patient, and propose an echocardiography-based goal-oriented hemodynamic approach to septic shock.

Recent findings

Echocardiography can play a key role in the critical septic patient management, by excluding cardiac causes for sepsis, and mostly by guiding hemodynamic management of those patients in whom sepsis reaches such a severity to jeopardize cardiovascular function. In recent years, there have been both increasing evidence and diffusion of the use of echocardiography as monitoring tool in the patients with hemodynamic compromise. Also thanks to echocardiography, the features of the well-known sepsis-related myocardial dysfunction have been better characterized. Furthermore, many of the recent echocardiographic indices of volume responsiveness have been validated in populations of septic shock patients.

Conclusion

Although not proven yet in terms of patient outcome, echocardiography can be regarded as an ideal monitoring tool in the septic patient, as it allows (a) first line differential diagnosis of shock and early recognition of sepsis-related myocardial dysfunction; (b) detection of pre-existing cardiac pathology, that yields precious information in septic shock management; (c) comprehensive hemodynamic monitoring through a systematic approach based on repeated bedside assessment; (d) integration with other monitoring devices; and (e) screening for cardiac source of sepsis.

Keywords

  • Sepsis
  • Septic shock
  • Echocardiography
  • Hemodynamic monitoring
  • Endocarditis
  • Critical care

Rationale for the use of echocardiography in the septic critical patient

Sepsis and septic shock (SS) are common causes of cardiovascular failure in critical care and are the most frequent causes of mortality in intensive care units [1, 2]. SS is one of the most complex hemodynamic failure syndromes, as it may imply derangement of all the three mainstays of cardiovascular homeostasis, each one to a variable degree: absolute or relative reduction in central blood volume, peripheral vasodilatation and myocardial failure may coexist and variably overlap in different phases of septic shock’s course [3, 4]. Echocardiography (ECHO) has nowadays acknowledged clear indications in hemodynamic instability [5], is increasingly used by intensive and critical care physicians, and is advocated by many as an irreplaceable tool in the approach to and management of the critical patient [6–8]. Many are the reasons that make ECHO suitable for guiding hemodynamic management of septic critical patients at different stages of their critical illness: (1) non-invasiveness, rapidity—in adequately trained hands ECHO has the potential to non-invasively provide at the bedside instantaneous relevant diagnostic information on patients’ cardiovascular status [9, 10]. Even though a comprehensive ECHO examination may be time consuming, time required for a focused, limited ECHO examination ranges from seconds to a dozen of minutes [11, 12]; (2) diagnostic yield, monitoring capabilities—ECHO offers the matchless advantage to perform both detailed functional and morphological assessment of the heart; pathological changes in venous return and vascular tone can then be assessed with dynamic investigation of their consequences on the heart and the great vessels [13–15]; (3) impact on patient management—even in patients already monitored invasively, both transthoracic ECHO (TTE) and transesophageal ECHO (TEE) add new relevant information that leads to changes in therapy in more than 50% of cases [12, 16, 17], the majority of which concern volume status and inotropy [17]; (4) flexibility—its use is scalable from a limited/focused to a comprehensive examination, according to time available and complexity of clinical queries. Either TTE or TEE can alternatively be used, according to availability and to the specific information needed; (5) accuracy—the use of ECHO as hemodynamic monitoring tool has already been validated in populations of septic shock patients [14], so as have been many of the most recent ECHO indices of volume responsiveness [18]. ECHO seems to be more accurate than the standardized strategy proposed by the Surviving Sepsis Campaign guidelines in the detection of the dominant features of the failing circulation [19]. Indeed, a simplified qualitative approach has demonstrated to be accurate enough [20]; (6) specific cardiac issues related to sepsis—the heart, main target of the ECHO examination, frequently represents itself the core of the septic process, being either “a victim” (when sepsis-related myocardial dysfunction develops) or its source (in the context of endocarditis).

The purpose of this review was to describe ECHO applications and potential findings in the critical septic patient, and provide a framework for the practical approach with Echo to SS management, both at onset and in the subsequent course of the disease.

Early management of the septic shock patient: focused echocardiography

Sepsis mortality is directly linked to hemodynamic instability resulting in tissue hypoxia, and prompt support aimed at specific hemodynamic targets has been demonstrated to reduce it significantly [21], up to saving the lives of one in six sepsis patient [22]. One key component of early goal-directed therapy strategies in SS is the accurate hemodynamic assessment and recognition of the dominant feature of the failing cardiovascular system (defective volume or vascular tone, failing heart pump) with subsequent appropriate management [23, 24]. Consistently with this need to accelerate the correct treatment, bedside TTE in the early phase of undifferentiated shock sharply reduces the number of viable diagnosis [25]. Focused ECHO findings typical of early SS (Table 1) are represented by signs of profound hypovolemia: ventricular hyperkinesia [small hypercontractile left ventricle, LV, with end-systolic obliteration of cavity [26] (Fig. 1a–c, Video 1A, B ESM), small hypercontractile right ventricle, RV] and small inferior vena cava with marked respiratory variations [27, 28] (Figs. 1e, f, 2a). Once this hemodynamic pattern has been detected, matched with clinical findings to make a presumptive diagnosis, and hemodynamic support started, an increase in inferior vena cava size [27] and in right and left ventricular end-diastolic dimensions [29] is expected with progression of volume resuscitation (Fig. 2b, c, Video 1 ESM). Persistent small end-systolic dimensions suggest then vasodilatation and need for vasoconstrictors upward titration. Furthermore, early performance of focused echo allows for timely screening of sepsis-related myocardial dysfunction and hence more careful fluid administration and early inotropic support (vide infra).
Table 1

Echocardiographic findings at shock onset

Small LV

Small RV

LV and RV hyperkinesia

Small IVC

IVC respiratory collapse (spontaneous ventilation)

None of the above (but rather a variable degree of LV or RV dysfunction) in the setting of relevant pre-existing cardiac disease

Typical echocardiographic findings at septic shock onset are represented by signs of severe hypovolemia and biventricular hyperkinesia (effect of co-existing vasodilatation and hypovolemia). These findings are easily recognizable with a TTE focused ECHO examination. Put in the clinical context of a febrile patient with a known/suspected septic focus, this pattern suggests diagnosis of septic shock. Recognition of signs of pre-existing cardiac disease avoids misdiagnosis of primary cardiogenic cause of shock in a chronic heart failure with septic shock

LV left ventricle, RV right ventricle, IVC inferior vena cava

Fig. 1
Fig. 1

Septic shock at its onset, in hospital-acquired pneumonia, 3rd postoperative month of double lung transplant. Patient intubated and mechanically ventilated. SAP 85/40 mmHg, HR 160 bpm, with signs of inadequate tissue perfusion. TTE subcostal 4-chamber view (upper panels, Video 1A ESM) and parasternal short axis midpapillary view (middle panels, Video 1B ESM) show a hyperkinetic pattern, with marked reduction of LV and RV size from end-diastole (a, c) to end-systole (b, d). Inferior vena cava (subcostal IVC view, lower panels) is small (e) and shows significant increase in size with mechanical passive inspiration (f). RA right atrium, RV right ventricle, LA left atrium, LV left ventricle, IVC inferior vena cava

Fig. 2
Fig. 2

Early septic shock in central venous line-related bloodstream infection. Spontaneously breathing patient. Severe hypotension. Very small IVC end-expiratory diameter (aright side) and marked inspiratory collapse (a, M-mode scanning, left side) are in favor of severe hypovolemia. Subsequent volume loading (colloids 1,000 ml, crystalloids 300 ml), improves SAP. This is paralleled by a progressive increase in IVC end-expiratory size (b, c, red double-headed arrows). IVC inferior vena cava, RA right atrium, INSP inspiratory phase of respiratory cycle, SAP systemic arterial pressure, HR heart rate

SS superimposing on pre-existing cardiac dysfunction, or sepsis-triggered cardiac derangements (myocardial ischemia), or aggressive mechanical ventilation (hindering RV function in the context of ARDS, pneumonia) may determine from the beginning a different pattern, where typical features are missing, and RV or LV dysfunction appears as the main finding. Recognition of a relevant dilatation of any cardiac chamber other than the RV (the only chamber that can dilate acutely) or dilatation and hypertrophy of the RV gives clues toward a subjacent chronic dysfunction, avoids misdiagnosis of a primary cardiogenic aetiology of shock [15], and bears prognostic information linked to relevant co-morbidity. Severe LV hypertrophy and/or LV diastolic dysfunction may represent potential pitfalls on ventricular size-based volume status assessment: in this case, persistent LV small dimension does not equate to safe fluid infusion. Fluid administration should altogether not be gauged on LV or RV dimensions in the aforementioned settings of co-existing chronic heart disease, but rather on inferior vena cava size, when small, and on volume-responsiveness indices (vide infra).

Additional focused ultrasound investigations (lung, abdominal, soft tissues, beyond the scope of this review) in a multi-focused transversal approach [30, 31] should help in confirming suspicion of a septic etiology of the critical state and save time in early institution of empirical antibiotic therapy, upon appropriate bacteriological sampling.

Monitoring the patient with septic shock: comprehensive echocardiography

While pattern recognition may suffice in the very early approach to SS [32], with ongoing resuscitation or more complex situations (ex. co-existing disease), a systematic step-by-step assessment is necessary to monitor hemodynamics. Repeated bedside assessment at each hemodynamic deterioration or significant therapeutic variation is the key to the use of Echo in this hemodynamic fashion [14] and allows for prompt recognition and correction of the specific causes of cardiovascular instability, which is mandatory in SS management [20, 24, 33]. ECHO findings should be appropriately interpreted in the clinical context and integrated with available data from other monitoring tools (systemic arterial mean pressure, central venous pressure and saturation, arterial blood lactates, urine output), especially with the ones concerning the adequacy of tissue perfusion, on which echocardiography is blind. TEE always enables a complete assessment, inclusive of detailed heart–lung interactions and fine volume responsiveness evaluation, cardiac output assessment, and left-ventricular end-diastolic pressures estimation, when required. When adequate views can be achieved, TTE allows for even less invasive and thus more repeatable assessment, especially once key hemodynamic features have already been focused. ECHO reporting and storage of images and video clips allow for accurate comparison of findings obtained at different time spots and should thus be mandatory.

ECHO assessment should systematically seek for the following situations (Table 2), with the aim to guide fluid therapy and inotropic/vasoconstrictor support institution and titration:
Table 2

Targets of the echocardiographic hemodynamic assessment

Cardiac output

Volume status, volume responsiveness

LV systolic function

RV systolic function

Systemic arterial resistances (indirect, exclusion criteria)

LV filling pressures

To monitor the septic shock patient, major hemodynamic variables are assessed non-invasively, mainly by semi-quantitation. Systemic arterial resistances, together with indices of global perfusion, cannot be measured with echocardiography, but vasodilatation can be diagnosed with exclusion criteria. See systematic approach in Fig. 8

LV left ventricle, RV right ventricle

Low output state

Stroke volume is calculated through Doppler sampling of LV outflow tract (LVOT) flows (TTE 5 chamber view or TEE deep TG/TG LAX view), and is feasible provided the absence of aortic valve pathology [34]. Doppler sampling provides the time–velocity integral of blood exiting the LV; this integral (a distance) is then multiplied by the calculated cross sectional area of the LVOT itself (TTE parasternal LAX view/ME LAX view), yielding a volume, the stroke volume and then turned into cardiac index (Fig. 3a, b). This method actually provides an estimation of cardiac index rather than a precise determination: most validation studies using thermodilution as gold standard for cardiac output measurement reported limits of agreement with TEE reaching ± 1 L/min [35]. In practice, ECHO is used to semi-quantify cardiac index (i.e. to allocate patients into ranges of values: very low/low/normal/high), and most usefully to evaluate variations following therapeutic maneuvres (Fig. 3c). Relying upon the LVOT velocity–time integral, rather than calculated stroke volume, eliminates the major source of error (i.e. LVOT cross-sectional area calculation). Furthermore, the issue of potential inaccuracy of thermodilution should not be overlooked [36]. Due to peripheral flow distributive derangements, usual normal values of CI should not be considered necessarily adequate in SS. Other ways to calculate the stroke volume include the 2D-based modified Simpson’s rule and the M-mode-based Teicholz method; even if easier in their approach, they are not sufficiently accurate to be recommended as routine practice.
Fig. 3
Fig. 3

TEE Doppler assessment of cardiac output in a community-acquired pneumonia patient with septic shock (same patient of Fig. 5). Patient is hypotensive and badly perfused and 2D images show a pattern of biventricular dysfunction. LVOT diameter is measured in a mid-esophageal long axis view (a, red double-headed arrow) and LVOT cross sectional area calculated (LVOT diameter = 2.23 cm; CSA = 1.115 cm × 1.115 cm × 3.14 = 3.90 cm2). Measured LVOT VTI (panel 3B, TEE transgastric long axis view) is 8.7 cm, calculated stroke volume is 34 ml (3.90 cm2 × 8.7 cm), and heart rate 104 bpm, yielding a CO of 3.55 L/min. Epinephrine infusion [0.01 mcg/(kg min)] restores adequate pressures and flows, increasing LVOT VTI to 12.7 cm, SV to 49 ml (3.90 cm2 × 12.7 cm), heart rate to 120 bpm and CO to 5.83 L/min (c). LVOT left ventricular outflow tract, VTI Doppler velocity–time integral, CO cardiac output

Inadequate central blood volume

After the first phase of shock resuscitation, signs of severe hypovolemia may still exist and be detected as a small LV end-diastolic area (LVEDA, easily measured in a TTE parasternal short axis or in a TEE transgastric midpapillary view). But most frequently a volume-resuscitated shock will need a volume responsiveness assessment in order to unmask a persistent preload defect [37]. Volume responsiveness can be detected with various ECHO indices (Table 3), but this assessment must be tailored to the clinical setting. In fully passive mechanically ventilated patients with sinus rhythm, indices derived from study of heart–lung interactions are highly accurate: ≥12.5% respiratory variation of LV ejection [38], ≥18% inferior vena cava distensibility [39] (TTE subcostal view), or ≥36% superior vena cava collapsibility [40] (TEE bicaval view) are validated cutoffs, with sensitivities and specificities ranging from 90 to 100% (Fig. 4). Low tidal volumes may yield false negatives [41], and severe RV dysfunction, for LVOT flows-based indices, false positives [42]. Spontaneous breathing and/or non-sinus rhythm requires a passive leg-raising test: a ≥12.5% LVOT velocity–time integral increase upon shift of patient position from 45° trunk elevation to 45° leg raising is predictive of SV increase with volume loading (Fig. 2 ESM) with 77% sensitivity and 100% specificity [43]. False negatives to the test may occur, especially in the context of abdominal hypertension for values of intrabdominal pressure >16 mmHg [44]. When still in doubt, an Echo-monitored fluid challenge (the search for ≥15% Echo-measured stroke volume increase upon a limited fluid bolus infusion) is indicated as last choice. Of note is that the existence of volume responsiveness is better supported by a bundle of ECHO findings rather than a single positive index, and that it does not necessarily equate to the need for fluid infusion (absolute hypovolemia correction); also recruitment of unstressed volume from the venous reservoir (relative hypovolemia correction) may increase cardiac output [45, 46]: when an upward titration of vasoconstrictors determines an increase in stroke volume, this may be the preferred choice toward limiting harmful positive fluid balance [47].
Table 3

Echocardiographic indices of volume responsiveness

∆Vpeak

100 (Vpeakmax − Vpeakmin)/(Vpeakmax + Vpeakmin)/2 [≥12%] [36]

IVC distensibility index

100 (IVCend-insp − IVCend-exp)/IVCend-insp [≥18%] [37]

SVC collapsibility index

100 [(SVCend-exp − SVCend-insp)/SVCend-exp] [≥36%] [38]

Response to PLR test

(SViPLR − SVibasal)/SVibasal [≥12.5%] [38]

Volume responsiveness can be accurately detected in passive mechanically ventilated and sinus rhythm patients through assessment of IVC and SVC diameter respiratory variations, and through LV ejection respiratory variations. In spontaneously breathing or mechanically ventilated but actively breathing patients, and/or non-sinus rhythm patients, these indices are inaccurate, and a passive leg-raising test is required. Cutoff values for volume responsiveness of each index are indicated in square brackets

Vpeak, peak velocity of transaortic flow; ∆Vpeak, aortic flow respiratory variation index; Vpeakmax, maximum Vpeak velocity; Vpeakmin minimum Vpeak velocity; IVC, inferior vena cava; IVCend-insp, IVC diameter at end inspiration; IVCend-exp, IVC diameter at end expiration; SVC, superior vena cava; SVCend-exp, SVC diameter at end expiration; SVCend-insp, SVC diameter at end inspiration; PLR, passive leg raising; SVibasal, stroke volume index at 45° trunk elevation; SViPLR, stroke volume index during PLR (45° leg raising)

Fig. 4
Fig. 4

Volume responsiveness assessment by means of heart–lung interaction-derived indices, in a mechanically ventilated passive patient with septic shock. Septic shock patient with peritonitis caused by colonic perforation. Left-sided panels show a volume responsiveness status, with marked respiratory SVC collapsibility (56%; a, TEE bicaval view, M-mode scanning), IVC distensibility (32%; c, TEE transgastric off-axis view on the IVC, M-mode scanning) and marked LV ejection respiratory variations (36%; e, TEE deep transgastric view, Doppler sampling of LVOT velocities). After 1,500 ml fluid infusion, these respiratory variations are greatly reduced and the various indices show now absence of volume responsiveness (right-sided panels): SVC collapsibility 18% (b), IVC distensibility 5% (d), LV ejection respiratory variations 10% (f). SVC superior vena cava, IVC inferior vena cava, SVCexp SVC diameter at end-expiration, SVCinsp SVC diameter at end-inspiration, IVCinsp IVC diameter at end-inspiration, IVCexp IVC diameter at end-expiration, Vpeak aortic blood flow velocity, VpeakMAX maximum Vpeak velocity, VpeakMIN minimum Vpeak velocity

LV systolic dysfunction

LV systolic function is assessed either visually (qualitatively), or by means of widely used 2D measurements (quantitatively). These are based on the percentage variation of LV size from end-diastole to end-systole, either referring to its diameter (FS, fractional shortening), its area (FAC, fractional area change), or its volume (EF, ejection fraction).

LV sepsis-related myocardial dysfunction is nowadays a well-known entity [48], and both global and regional systolic wall motion abnormalities can be found [49, 50]. A so-called hypodynamic pattern (low cardiac index associated with reduced ejection fraction, EF, below 40–45%) is described in up to 60% of SS patients [14, 51]: its detection should prompt inotropes administration, even if central venous pressure values indicated by guidelines as target for ceasing volume loading have not been reached yet (further increase in preload on an acutely failing LV may not only fail to increase oxygen delivery but may also cause harm). Sequential determinations of EF, FAC and FS will allow for appreciation of LV dysfunction’s complete recovery in survivors (Fig. 5, Video 5A, C ESM) [52, 53]. Time pattern of this phenomenon has been characterized: dysfunction appears usually on day 1 roughly in two-thirds of affected patients, on day 2–3 in the other third, while recovery takes 7–10 days. (Fig. 3 ESM) [51]. As sepsis-related myocardial dysfunction can be masked by associated vasodilatation and preload inadequacy, LV systolic function should always be re-assessed after preload and afterload optimization (Fig. 6, Video 6A, B). Conversely to what previously believed, there is no LV adaptive dilatation to this transient systolic function reduction (a relevant increase in chamber dimension to compensate for a reduced contractility): even if referred to as “dilatation” also by some recent echocardiographic literature[54], no acute relevant increase of LV size beyond upper limits of the normality range is to be expected in a previously healthy septic-depressed LV [53, 55], but rather changes is LV size according to different loading conditions in distinct phases of SS. Of note, ECG helps to distinguish between acute coronary syndrome-determined dysfunction triggered by sepsis (with electrical signs of ischemia) from true sepsis-related myocardial dysfunction (negative ECG for ischemia). Cardiac troponins show increases in both cases [56]. Myocardial perfusion ECHO may be a promising technique to allow for differential diagnosis [57].
Fig. 5
Fig. 5

Sepsis-related myocardial dysfunction. Septic shock in a patient with community-acquired pneumonia (same patient of Fig. 3). Repeated TEE assessments (mid-esophageal 4-chamber views). At ICU admission [SAP 110/70 mmHg, HR 118 bpm, norepinephrine 0.4 mcg/(kg min)] a pattern of severe biventricular dysfunction is detected (Video 5A ESM), as evidenced by a small reduction of both ventricle’s size from end-diastole (a) to end-systole (d); measured EF is 15%, TAPSE 12,9 mm, CO 3,59 L/min. Hemodynamic improvement occurs after epinephrine infusion at [0.1 mcg/(kg min)] (b–e, Video 5B ESM): SAP 140/76, HR 122 bpm, EF 25%, TAPSE 15.7 mm, CO 4.83 L/min. On day 12 patient is weaned from vasoactive drugs (c–f, Video 5C ESM): SAP 130/68, HR 93 bpm, EF 58%, TAPSE 21.1 mm, CO 6.43 L/min. Note that the LV looks dilated in a and b, but only if compared with its size after recovery (c), and not as absolute value (LV EDV = 146 ml, upper range of normality). RA right atrium, RV right ventricle, LA left atrium, LV left ventricle, EF ejection fraction, TAPSE tricuspid annulus plane systolic excursion, CO cardiac output

Fig. 6
Fig. 6

Septic shock after preload and afterload optimization, unmasking sepsis-related myocardial dysfunction. Same patient of Fig. 1 (hospital-acquired pneumonia, 3rd postoperative month of double-lung transplant), 18 h later, after volume resuscitation, infusion of norepinephrine [1 mcg/(kg min)], vasopressin 0.02 U/min, now again unstable (SAP 90/60, HR 121 bpm, low cardiac output). TTE subcostal 4-chamber view (upper panels, Video 6A ESM) and parasternal short axis midpapillary view (middle panels, Video 6B ESM) show a severely depressed LV systolic function with negligible reduction of LV size from end-diastole (a, c) to end-systole (b, d). RV shows preserved systolic function. The IVC (subcostal IVC view, lower panels) is now larger (e) with absent inspiratory increase at mechanical passive inspiration (f). RA right atrium, RV right ventricle, LA left atrium, LV left ventricle, IVC inferior vena cava, SAP systemic arterial pressure, HR heart rate

RV systolic dysfunction

RV systolic dysfunction can also develop in SS, and it is been described in up to one-third of patients [14, 58]. It can either be part of biventricular dysfunction or represent an isolated RV dysfunction. Intrinsic depression of RV myocardial function is detected as RV hypokinesia, and semi-quantitatively appreciated as a variable degree of RV dilatation (with RV end-diastolic area, RVEDA, to LV end-diastolic area, LVEDA, ratio measurement in a four chamber view). When RV systolic overload (due to ARDS, mechanical ventilation) develops [59], or even worse superimposes on an already poor RV function, an overt state of acute cor pulmonale can appear, and it is revealed by septal dyskinesia (Fig. 7, Video 7A, B) [60]. With introduction of lung protective ventilation strategies, frequency of this phenomenon has markedly decreased [61], and RV dilatation represents the most frequent finding. Such as LV dysfunction may be unmasked by vasoconstrictors administration, so can RV failure become manifest only upon institution of mechanical ventilation. Time course of sepsis-related RV dysfunction resembles that of LV dysfunction [48]. Whenever detected as main hemodynamic feature (in the ARDS setting), not only inotropes administration but also vasoconstrictors upward titration is indicated, together with low plateau pressure of ventilation; this hemodynamic pattern may also represent an indication for inhaled nitric oxide administration and for patient’s pronation [60, 61].
Fig. 7
Fig. 7

Acute cor pulmonale in septic shock. Septic shock in community-acquired pneumonia superimposed on chronic pulmonary hypertension (pulmonary fibrosis). TEE midesophageal 4-chamber view (upper panels, Video 7A ESM) and transgastric midpapillary short axis view (lower panels, Video 7B ESM). SAP 100/53 mmHg, HR 123 bpm, low cardiac output. Norepinephrine [1 mcg/(kg min)] is infused. The RV looks markedly dilated (its end-diastolic area is bigger than the LV area (7A, RVEDA/LVEDA > 1), and hypokinetic (small reduction of its size from end-diastole, a, to end-systole, b). The interventricular septum is flattened (a, c) and shows a paradoxical motion at end-systole (b, d, red arrow). RA right atrium, RV right ventricle, LA left atrium, LV left ventricle, RVEDA RV end-diastolic area, LVEDA LV end-diastolic area

Low peripheral vascular tone

Echocardiography offers theoretically the tools to calculate systemic arterial vascular resistance but with a cumbersome method and infrequent clinical applicability. In clinical practice, sepsis-related vasodilatation is diagnosed with exclusion criteria: persistence of hypotension despite adequate preload and preserved (or pharmacologically normalized) biventricular systolic function, and thus absence of a low-output state, invariably means a need for an increase in systemic arterial vascular tone [15]. As mentioned above, also in some situations of volume responsiveness upward titration of vasoconstrictors is indicated.

LV diastolic dysfunction, LV filling pressure

Additionally, assessment of LV diastolic properties and LV filling pressures estimation may be of use. Diastolic dysfunction has been demonstrated in SS patients using relatively preload-independent parameters, based on mitral annulus tissue Doppler and mitral inflow propagation velocity; not only as associated with systolic dysfunction, but also as isolated impairment of LV relaxation [62, 63]. Even if clinical implications of this still have to be fully clarified, practical impact may be derived for patients with isolated diastolic dysfunction and evidence of elevated LV filling pressures in the context of hypoxemia: fluid restriction and diuretics are then consistent choices (patients with systolic dysfunction do not viceversa risk to remain undetected, as they already usually are submitted to such a tretment, toghether with inotropes). Various Doppler-derived parameters provide estimation of LV filling pressure with good correlation to invasively measured pulmonary artery occlusion pressure (PAOP), specifically in septic shock patients populations [64]. In mechanically ventilated patients, mitral E/A < 1.4, pulmonary vein S/D > 0.65 and systolic fraction >44% best predict a PAOP ≤ 18 mmHg [65]; lateral E/E′ < 8.0 or E/Vp < 1.7 predicts a PAOP ≤ 18 mmHg with a sensitivity of 83 and 80% [65]; mitral E/A > 2 predicts a PAOP > 18 mmHg with 100% positive predictive value [66].

A structured approach integrating assessment of these hemodynamic targets into a practical algorithm is proposed in Fig. 8.
Fig. 8
Fig. 8

Septic Shock ECHO-based goal-directed algorithm. To monitor hemodynamics in septic shock the targets of the echocardiographic investigation are organized in a systematic five-step approach. Starting point is to detect potential signs of pre-existing chronic cardiac dysfunction (Step 1): LV or LA significant dilatation, and LV marked hypertrophy are signs or chronic volume/pressure overload; RA significant dilatation, RV dilatation and hypertrophy have the same meaning for right-side chronic disease (isolated RV dilatation can vice versa be a sign of acute RV dysfunction). If unrecognized, these findings can mislead in interpretation of subsequent findings (i.e. primary cardiogenic cause of shock, instead of sepsis; wrong assessment of volume status based on LV or RV dimensions). LV and RV systolic function must then be assessed (Step 2), together with cardiac output Doppler measurement (Step 3). A low output state can then be ascribed to sepsis-related LV systolic dysfunction (associated or not to RV dysfunction) or isolated RV dysfunction, and treated accordingly. Low output with evidence of normal biventricular systolic function should prompt investigation of volume status (Step 4): overt hypovolemia or presence of volume responsiveness will lead to fluid infusion. When inadequacy of global perfusion and/or hypotension is associated with a non-low output state, persistent preload defect should be investigated (again step four) and if detected corrected. If this is not the case, an exclusion diagnosis of vasodilatation is made (Step 5), and systemic arterial tone corrected with upward titration of vasopressors. Whenever this is done, LV systolic function should subsequently be re-assessed, as normalization of LV afterload can unmask sepsis-related myocardial dysfunction. If chronic LV failure is found, or LV dysfunction develops acutely, LV filling pressure estimation is mandatory, to guide fluid management and differential diagnosis of potential hypoxemia and pulmonary edema (cardiogenic vs. non cardiogenic). ScvO2 central venous saturation, LV left ventricle, RV right ventricle, SV stroke volume, CI cardiac index, SAPm mean systemic arterial pressure

Cardiac source of sepsis

Infective endocarditis (IE) is a microbial infection of intracardiac structures facing the blood. It can be encountered in ICU patients mainly in two scenarios: (A) as cause of admission, due to severity of its complications leading to cardiogenic shock in a febrile context, or to pure septic shock; (B) as acquired infection during ICU stay, leading to a septic state with no evident focus.

  • IE on native or prosthetic valves is defined on the bases of a well-established set of diagnostic criteria [67, 68], and echocardiography provides for one of the major ones. IE is a severe disease with a high mortality, ranging from 20 to 25% [69] and up to 45% in patients then admitted to ICU [70]. Echocardiography highly contributes to IE diagnosis, allows for severity assessment, and has a pivotal role in IE management and decision making both on therapy and complications [71, 72].

    Three potential ECHO findings are deemed to be important criteria in establishing an IE diagnosis (Table 4): (A) mobile echo dense mass attached to valvular or mural endocardium or to implanted material (Fig. 9a–d, Video 9A, B, Video 10–11 ESM), (B) paravalvular fistulae or abscess formation (Fig. 9d, Video 12 ESM), and (C) new disruption or dehiscence of a prosthetic valve (paravalvular leak) (Video 13 ESM). In severely damaged native valves (especially rheumatic), clear identification of small vegetations may be very difficult. Differential diagnosis between prosthetic valve IE and non-obstructive thrombus, or between bioprosthetic valve IE and degeneration, can be very challenging.
    Table 4

    Echocardiographic findings suggestive of endocarditis

    Mobile echo dense mass attached to valvular/mural endocardium, or to implanted material

    Paravalvular fistulae or abscess formation

    New disruption or dehiscence of a prosthetic valve (paravalvular leak)

    Even if echocardiography alone cannot be used to make diagnosis of infective endocarditis, combination of clinical-instrumental-microbiological criteria with detection of at least one of these findings does

    Fig. 9
    Fig. 9

    Infectious endocarditis in ICU patients. a Patient with septic shock, acute pulmonary edema, and systemic arterial embolization (TEE midesophageal long axis view): massive mobile vegetation (white arrow) on native aortic valve (right cusp; note also anatomic disruption of the non-coronary cusp). See also Video 9A, B ESM. b Febrile dyspnoeic patient (TEE midesophageal long axis view): thin vegetations and cusps perforation on native aortic valve (white arrows). See also Video 10 ESM. c Septic shock patient (TEE midesophageal commissural view): small linear vegetation (white arrow) on prosthetic valve in mitral position. See also Video 11 ESM. d Patient with cardiac tamponade (bloody fluid at pericardiocentesis) and septic shock (TEE midesophageal 2-chamber view): huge mobile vegetation incorporating the posterior mitral leaflet (white arrow); note sub-annular abscess and escavation (red arrow) responsible for subacute LV wall rupture and hemopericardium. See also Video 12 ESM. In Video 13 ESM see in another febrile ICU patient a paravalvular leak, regurgitant jet originating outside the prosthetic valve annulus (red arrow; TEE midesophageal 2-chamber view, mechanical bileaflet valve in mitral position). e Febrile patient with dilated cardiomyopathy and biventricular pacing device (TEE bicaval view): thrombus is evident in the SVC (red arrow), attached to the pacemaker wire (white arrow). See also Video 14 ESM. Note pulmonary embolic lesion at CT-scan (f, red arrow). RA right atrium, LA left atrium, LV left ventricle, Asc AO ascending aorta, SVC superior vena cava

    Relevant differences in diagnostic accuracy for IE exist between the transthoracic and the transesophageal technique. Compared with TTE [73, 74], TEE has greater sensitivity on small vegetations and on mitral valve IE. Both techniques reach high specificity in equal manner, and detection of a vegetating mass with focused TTE in first approach to a shocked patient can be lifesaving.

    The clinical context influences TTE and TEE diagnostic capability [75]: while with low IE pre-test probability a negative good-quality TTE can exclude the diagnosis, TEE should be performed on all TTE negative cases with a more-than-low clinical suspicion.

    In mechanically ventilated ICU patients TEE is almost invariably needed. It is then mandatory in the assessment of suspected prosthetic valves IE, and in TTE positive cases to identify major valvular complications and guide surgical planning [76].

    Of particular note is that the clinical presentation of IE in acutely ill patients can be very much variable, ranging from a febrile state, to septic or cardiogenic shock, to any embolic manifestation. Echocardiography alone cannot be used to make diagnosis of IE: a combination of clinical-instrumental-microbiological criteria is required, and differential diagnosis between IE vegetations and other intracardiac masses should always be considered.

    Even if one-third to a half of IE develop in absence of pre-existing cardiac pathology or prosthetic devices, a high suspicion for IE should be kept for septic patients with prosthetic valves, implantable devices, or known significant native valve pathology, and for ICU bacteriemic patients with unknown septic focus.

  • IE on indwelling central venous catheters or implantable devices (pace-makers, internal cardioverters-defibrillators) is uncommon due to the lack of the hemodynamic factors usually involved in IE pathogenesis (flow turbulence, high pressure gradients) [77], but is getting more frequent as a consequence of development and increased use of invasive diagnostic and therapeutic procedures. In an ICU septic patient with no other clear infective focus it should thus be considered, especially if evidence of pulmonary septic embolism exists [78] (Fig. 9e, f, Video 14 ESM). Besides searching for vegetations on the catheter, from superior vena cava to its implantation on the myocardium, the ECHO exam should seek carefully for IE-associated localizations on right heart valves [77–81]. Visualizing vegetations on implantable devices (mass or sleeve-like) may be difficult, due to artifacts coming from the device itself. Small fibrin strands may represent a difficult differential diagnosis.

  • Septic thrombus on temporary central venous catheters in ICU patients [82] and right heart endocarditis following pulmonary heart catheterization have also been described [83]. Finding of masses on central venous catheters, more frequent, should prompt to consider non-septic thrombosis as differential diagnosis with EI. Microbiological data become obviously crucial.

Limitations of Echo in diagnosis and monitoring the critical septic patient

Even if ECHO has been extensively validated as accurate and safe, and is currently employed on septic critical patients by many clinicians, real outcome data related to its use (beyond simple demonstration on impact on patient management) are lacking.

Limitations in its use also exist. Low echogenicity at surface examination matched with contraindications to TEE clearly prevent its use. Whenever there is strict requirement of continuous monitoring (of cardiac output or pulmonary artery pressure) or precise measurement rather than estimation of deemed relevant variables (mainly PAOP or extravascular lung water), ECHO is not the right tool. In centres where a tradition and adequate training on the use of critical care ECHO exist, this is no frequent [14], and repeated bedside assessment and semi-quantification of hemodynamic variables enable use of ECHO alone as monitoring tool. As it happens with targets of critical care practice other than hemodynamics, integrated monitoring remains fundamental, and ECHO is in the best position to be used in conjunction with other devices (pulse contour technique based cardiac output monitors, pulmonary artery catheter, PiCCO) [13]. Indeed, it can guide choice between them and timing of use. A final issue is represented by time required to the clinician to acquire sufficient competence in critical care ECHO. For applications beyond focused ECHO, particularly comprehensive hemodynamic monitoring, the training may in fact be demanding [8], and not all physician may be willing to undergo a dedicated training.

Conclusions

Echocardiography marries diagnostic capability with monitoring accuracy, morphological assessment with functional investigation. In the complex scenario of the critical septic patient it has therefore the potential to be regarded as an ideal monitoring tool, in most circumstances used alone, sometimes in combination with other devices. Beyond the very first stages of septic shock, where focused ECHO may suffice, a comprehensive systematic ECHO assessment of cardiac output, left and right systolic ventricular function, volume status and filling pressures is required, and allows for effective hemodynamic management. Unfortunately, outcome studies on the use of ECHO in septic shock are lacking, and are therefore strongly advocated. As a matter of fact, availability of ECHO equipment and adequate training remain actual major limitations on a wider use of ECHO in this setting.

Declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Authors’ Affiliations

(1)
1st Department of Anesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi, 2, 27100 Pavia, Italy
(2)
Adult Intensive Care Unit, Royal Brompton Hospital, London, UK
(3)
General ICU, Azienda Ospedaliera Niguarda Ca’ Granda, Milan, Italy

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