Table 6 Comparison of different diagnostic strategies incorporating Wells score, d-dimer measurement and LUS in 141 patients with pleuritic chest pain and available data on d-dimer, from Reissig 2001 and Nazerian 2017 studies
- Wells score ≤ 4 - Negative d-dimer | - Wells score ≤ 4 - Negative LUS | - Wells score ≤ 4 - Negative d-dimer - Negative LUS | - Wells score ≤ 4 - Negative LUS (painful area) | |
|---|---|---|---|---|
Failure rate* | 6.7% (1.9–16.2) | 3.7% (0.8–10.6) | 0% (0–6.5) | 4.9% (1.36–12.2) |
Efficiency** | 42.5% (34.3–51.2) | 56.7% (48.1 -65) | 39% (30.9–47.6) | 57.4% (48.8–65.7) |
Sensitivity | 90.7% (77.9–97.4) | 93% (80.9–98.5) | 100% (91.8–100) | 90.7% (77.9–97.4) |
Specificity | 57.1% (46.7–67.1) | 78.6% (69.1–86.2) | 56.1% (45.7–66-1) | 78.6% (69.1–86.2) |
PPV | 48.1% (42–54.3) | 65.6% (55.4–73.7) | 50% (44.4–55.6) | 65% (55.7–73.3) |
NPV | 93.3% (84.4–97.3) | 96.2% (89.6–98.7) | 100% | 95.1% (88.3–98) |
LR + | 2.12 (1.65–2.71) | 4.34 (2.95–6.4) | 2.28 (1.82–2.85) | 4.23 (2.86–6.26) |
LR- | 0.16 (0.06–0.42) | 0.09 (0.03–0.27) | 0 | 0.12 (0.05–0.3) |