Table 5 Comparison of different diagnostic strategies incorporating wells score, d-dimer measurement and LUS in 451 patients from Reissig 2001 and Nazerian 2017 studies

Failure rate*

4.1%

(1.4–9.4)

12.4%

(8.5–17.4)

0.9%

(0.02–4.9)

Efficiency**

26.8%

(22.8–31)

51.7%

(46.9–56.4)

24.8%

(20.9–29.1)

Sensitivity

96.6%

(92.3–98.9)

80.5%

(73.3–86.6)

99.3%

(96.3–100)

Specificity

38.4%

(32.9–44.1)

67.5%

(61.9–72.8)

36.8%

(31.3–42.5)

PPV

43.5%

(41.2–45.8)

55%

(50.6–59.5)

43.7%

(41.5–45.8)

NPV

95.9%

(90.6–98.2)

87.6%

(83.9–91.2)

99.1%

(94–99.9)

LR + 

1.57

(1.43–1.72)

2.48

(20.07–2.97)

1.57

(1.44–1.71)

LR-

0.09

(0.04–0.21)

0.29

(0.21–0.41)

0.02

(0–0.13)