Increasing illness severity is associated with global myocardial dysfunction in the first 24 hours of sepsis admission

The Ultrasound Journal

Table 3 Mixed-effects model results showing the relationship between emergency department Sequential Organ Failure Assessment Score and marginal mean of echocardiography parameters

	ED SOFA score
	Parameter estimate	95% CI	Percent residual variation not explained by within-subject effects	Number of observations included (%)
Echocardiography measure
LVEF (%)	− 1.84	− 2.88 to − 0.80	59.5	185 (84)
TAPSE (mm)	− 0.72	− 1.2 to − 0.50	39.6	103 (47)
GLS (%)	0.30	− 0.01 to 0.61	84.3	85 (39)
Lateral e′(cm)	− 0.04	− 0.1 to − 0.02	31.2	147 (67)
Septal e′ (cm)	− 0.04	− 0.05 to − 0.01	53.0	149 (68)
Average e′ (cm)	− 0.04	− 0.10 to − 0.01	52.2	139 (63)
Lateral E/e′	0.98	0.29 to 1.67	71.3	126 (58)
Septal E/e′	1.28	0.44 to 2.11	73.1	126 (58)
Average E/e′	1.13	0.37 to 1.88	75.0	126 (58)

Each row represents a single linear mixed-effects model with the outcome being repeated measures (at 0, 3 and 24 h) of the cardiac function parameters listed in column 1 and the parameter estimate for ED SOFA score (covariate parameter estimates not shown)
LVEF left-ventricular ejection fraction; TAPSE tricuspid annular plan systolic excursion; GLS global longitudinal strain; e′ mitral annular velocity; E/e trans-mitral inflow velocity/mitral annular velocity ratio