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Table 1 Baseline patient characteristics

From: Increasing illness severity is associated with global myocardial dysfunction in the first 24 hours of sepsis admission

  In-hospital mortality Overall cohort
Yes (N = 17) No (N = 56) N = 73
Age* 66.3 (12.9) 60.2 (14.7) 60.7 (15.6)
Female 4 (23, 1–46) 24 (43, 31–57) 28 (38, 28–51)
ED systolic BP 102 (33) 103.5 (39) 103 (37)
ED diastolic BP 66 (24) 68.0 (27) 64.7(27)
ED heart rate* 104 (21) 103 (24) 103 (23)
ED respiratory rate 20 (4) 20 (6) 20 (6)
ED Sp02 98 (3) 98 (4) 98 (3)
ED temperature 36.9 (2) 36.9 (1.2) 36.9 (1.5)
Weight (kg)* 70.6 (12.3) 74.5 (17.1) 74.9 (17.3)
Past medical history  
 Diabetes 10 (59, 36–78) 21 (38, 26–51) 31 (42, 32–54)
 Stroke 5 (29, 13–53) 11 (20, 11–32) 16 (22, 14–33)
 End-stage renal disease 6 (35, 17–59) 13 (23, 14–36) 19 (26, 17–37)
 Coronary artery disease 4 (24, 10–47) 14 (25, 15–38) 18 (25, 16–36)
 Cancer 9 (53, 31–73) 17 (30, 19–43) 26 (36, 26–47)
 COPD/asthma 4 (24, 10–47)) 12 (21, 12–34) 16 (22, 14–33)
 Heart failure (pEF or rEF) 5 (29, 13–53) 9 (16, 9–28) 14 (19, 12–30)
Laboratory results and interventions  
 ED Lactate (mmol/L) 4.3 (2.9) 2.9 (1.9) 3.1 (2)
 ED Troponin-I (ng/mL) 0.07 (0.07) 0.05 (0.05) 0.06 (0.05)
 NT-pro BNP (pg/mL) 1562 (0) 135.5 (107) 180 (555)
 Hemoglobin (mg/dL) 10.4 (2.55) 11.2 (4.1) 11 (3.3)
 Creatinine (mg/dL) 2.69 (2.77) 2.05 (3.04) 2.06 (2.76)
 IVF 3 h (L) 2.0 (1.5) 2.0 (2.0) 2.0 (2.0)
 IVF 24 h (ml) 3600 (2800) 3145 (3100) 4.5 (3.0)
 30 cc/kg in 1st 3 h 10 (59, 30–90) 28 (58, 37–65) 38 (52,
 SOFA score: ED 5 (4) 3 (5) 3 (5)
 SOFA score: 24 h 6.5 (7) 2 (5) 3 (5)
 Mechanical ventilation 9 (53, 31–74) 10 (18, 10–30) 19 (26, 17–37)
 Vasopressor use 9 (53, 31–74) 10 (18, 10–30) 19 (26, 17–37)
 Days in Hospital 6 (10) 7 (7) 6.5 (7.0)
Primary source of infection# (%, N)  
 Pneumonia 41 (7) 34 (19) 36 (26)
 GI/GU 35 (6) 38 (21) 37 (27)
 Skin/soft tissue/bone 6 (1) 3 (2) 4 (3)
 Other 18 (3) 25 (14) 23 (17)
  1. Proportions are given as N (%, 95% CI); continuous variables given as median (inter-quartile range) except as denoted by *, which are given as mean (standard deviation)
  2. BP  blood pressure; COPD  chronic obstructive pulmonary disease; LVEF  left-ventricular ejection fraction; pEF/rEF  preserved/reduced LVEF; TAPASE  tricuspid annular plan systolic excursion; Avg e′  average of septal and lateral mitral annular velocities; IVF  intravenous fluid; SOFA  sequential organ failure assessment; ED  emergency department; GI  gastrointestinal; GU  genitourinary; Other  indwelling vascular access device, bacteremia, or source unknown
  3. #Some patients had more than one infectious source identified on chart review—only the primary source is listed here