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Table 3 Risk of bias and applicability concerns summary

From: Diagnostic value of transcranial ultrasonography for selecting subjects with large vessel occlusion: a systematic review

  Risk of bias Applicability concerns
Patient selection Index test Reference standard Flow and timing Patient selection Index test Reference standard
Akopov and Whitman [19] High Low Unclear Low Low Low Low
Bar et al. [23]a Low Low Low High Low Low Low
Boddu et al. [24] Low Low Low Low Low Low Low
Brunser et al. [25]a Low Low Low Unclear Low Low Low
Gerriets et al. [26] Low Low Low Low Low Low Low
Gerriets et al. [27] Low Low Low High Low Low Low
Goertler et al. [41] Unclear High High Unclear High Low Low
Guan et al. [28]a Unclear Low Low Low Unclear Low Low
Kadimi et al. [43] Unclear Unclear Unclear Low Low Low Low
Kenton et al. [29] Unclear Low Low High Low Low Low
Kern et al. [30] Low Low Low Low Low Low Low
Kukulska-Pawluczuk et al. [44] Unclear Unclear Low High Low Low Low
Leanyvari et al. [45] High Low High Low Low Low High
Matsumoto et al. [31] Low Low Low Unclear Low Low Low
Nasr et al. [32] Low Low Low High Low Low Low
Ovesen et al. [42] Low High Low High Low Low Low
Panerai et al. [20] High High High Low High Low High
Rathakrishnan et al. [33]a High Low Low Unclear Low Low Low
Seidel et al. [34] High Low Unclear Low Low Low Low
Seidel et al. [35] Unclear Low Unclear Low Low Low Low
Stolz et al. [36] Unclear Low Unclear Low Low Low Low
Tang et al. [37] Low Low Unclear High Low Low Low
Tsivgoulis et al. [38]a Low Low Low Low Low Low Low
Tsivgoulis et al. [39]a Unclear Low Low Low Low Low Low
Viola et al. [21] High Unclear High High Low Low High
Wada et al. [40]a Low Low Low Low Low Low Low
Zubkov et al. [46] Unclear High Unclear High Low Unclear Low
  1. Review author’s judgement about each domain for each included study
  2. Studies marked with an “a” were included in the quantitative analysis