Diastolic dysfunction and mortality in early severe sepsis and septic shock: a prospective, observational echocardiography study

The Ultrasound Journal

Table 4 Clinical and echocardiographic findings based on presence of systolic and/or diastolic dysfunction

Characteristic	Normal	Systolic dysfunction (LVEF < 45 %)	Isolated diastolic dysfunction (grades I, II, and III)	p value
Patients (N, %)	36 (50 %)	19 (26.4 %)	17 (23.6 %)
Age (years, mean)	51.6	50.9	58.6	0.21
Female (%)	50 %	47.4 %	64.7 %	0.53
APACHE II (mean)	22.0	25.9	25.3	0.03
BMI (kg/m², median)	28.6	26.9	28.9	0.45
e’ (cm/sec, median)	9.97	8.06	7.05	<0.01
E/e’	9.7	12.3	11.6	0.31
DT (ms, median)	156	129	180	0.003
E/A (median)	1.17	0.94	0.87	0.03
VFD (days, mean)	19.4	10.5	26.7	0.72
ICU-free days (median)	23.9	23.6	23.6	0.93
28-day mortality (mean)	13.9 %	10.5 %	17.6 %	0.83

Clinical and echocardiographic findings among patients with normal, impaired systolic,and isolated impaired diastolic function, on initial echocardiogram. APACHE II, Acute Physiology, Age, Chronic Health Evaluation score; BMI, body mass index; e’, early peak velocity of the septal mitral annulus using tissue Doppler imaging; E, early peak mitral inflow velocity using spectral Doppler; A, atrial peak mitral inflow velocity using spectral Doppler; DT, mitral deceleration time; VFD, ventilator-free days.